Efficacy and safety of a purified porcine insulin zinc suspension for managing diabetes mellitus in dogs     

Monroe WE  Laxton D  Fallin EA  Richter KP  Santen DR  Panciera DL  Towell TL  Williams KA  Hart JR  Hill S  Finkler MR  Shinn JS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(5):675-682

The objective of this study was to evaluate the safety and efficacy of a purified porcine insulin zinc suspension for treating dogs with uncomplicated diabetes mellitus. Fifty-three dogs were treated for 60 days after an initial dose determination period. The means of the blood glucose concentrations during 12-hour glucose curves and the means of the blood glucose nadir concentrations during 12-hour glucose curves for all dogs were determined before beginning insulin therapy (time 0), at the end of the dose determination period (time 1), 30 days after time 1 (time 2), and 60 days after time 1 (time 3). Presence of polyuria, polydipsia, and ketonuria was determined at each time point. Adequacy of control of hyperglycemia was based on 12-hour blood glucose curves and improvement in clinical variables (results of physical examinations, historic information, polyuria, polydipsia, and ketonuria). Safety was evaluated by questionnaire, performance of physical examination, CBC, serum chemistry profile, and urinalysis. The means of the blood glucose concentrations during 12-hour glucose curves and the means of the blood glucose nadir concentrations during 12-hour glucose curves for all dogs at times 1, 2, and 3 were significantly lower compared with time 0 (P < .0001). There was a reduction in the proportion of dogs with polyuria, polydipsia, and ketonuria of 82, 86, and 80%, respectively. All of the dogs had adequate glycemic control at time 1, 66% at time 2, and 75% at time 3. At time 3, 66% of dogs required insulin injections q12h. Other than hypoglycemia, there were no important adverse effects of insulin administration. The insulin, was safe and efficacious for reducing blood glucose and clinical signs in dogs with diabetes mellitus.  相似文献   

Comparison of diazepam with progestin for effectiveness in suppression of urine spraying behavior in cats.     

L Cooper  B L Hart 《Journal of the American Veterinary Medical Association》1992,200(6):797-801

The most common treatment for urine spraying and marking in cats has been administration of long-acting progestins. Treatment with diazepam has recently been gaining favor, particularly because of reported adverse effects of progestins. Results of a clinical trial involving 20 cats indicated that diazepam was effective in eliminating or markedly reducing spraying in 11 (55%) of them. However, most cats required continuous treatment, or at least intermittent treatment, when spraying recurred. The physiologic and behavioral dependency of cats on diazepam, which presumably develops over the course of administration, may contribute to the tendency for spraying to recur once diazepam treatment is discontinued. Using data from previously published findings on progestin administration, plus additional cases, it was documented that a significantly (P less than 0.05) higher percentage of males than females responded favorably. Although the number of cases was not sufficient for a statistical comparison of diazepam vs progestin treatment with regard to male vs female, possible gender difference in the effectiveness of diazepam was not indicated.  相似文献   

CSL VETERINARY HANDBOOK     

L. Hart 《Australian veterinary journal》1969,45(7):325-325

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Fell Pony syndrome in a pony in North America     

Gardner RB  Hart KA  Stokol T  Divers TJ  Flaminio MJ 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(1):198-203

A 5-week-old Fell Pony colt was examined for fever, lethargy, and anemia. The colt had been lethargic for 1 week before examination, had continued to nurse, had a temperature of 104°F (40°C), and was treated with ceftiofur (5 mg/kg IM q12h). Approximately 36 hours before examination, the colt developed watery diarrhea. Blood work performed by the referring veterinarian on the day of admission revealed a PCV of 10%.  相似文献   

Gluteal pyomyositis associated with septic proximal femoral physitis in a 12-day-old Standardbred filly foal     

Hart JC  Smith C  Mogg TD 《Australian veterinary journal》2006,84(10):371-374

A 12-day-old Standardbred filly foal was presented with an acute onset hindlimb lameness of 24 hours duration. Initial ultrasonographic evaluation of the right gluteal region revealed oedematous change to the muscle architecture. Conservative therapy consisting of antimicrobials and stall rest was initiated. Forty-eight hours after admission a localised gluteal pyomyositis had developed. This was drained twice by percutaneous aspiration. Four days after admission the foal was euthanased. Necropsy examination revealed a septic proximal femoral physis with no grossly apparent joint involvement.  相似文献   

Host and environmental reservoirs of infection for bovine digital dermatitis treponemes     

Evans NJ  Timofte D  Isherwood DR  Brown JM  Williams JM  Sherlock K  Lehane MJ  Murray RD  Birtles RJ  Hart CA  Carter SD 《Veterinary microbiology》2012,156(1-2):102-109

Bovine digital dermatitis (BDD) is a global infectious disease causing lameness of cattle and is responsible for substantial animal welfare issues and economic losses. The causative agents are considered to be spirochetal bacteria belonging to the genus Treponema, which have consistently been identified in BDD lesions worldwide. One potential means of controlling infection is the disruption of transmission; however, the infection reservoirs and transmission routes of BDD treponemes have yet to be elucidated. To address these issues, we surveyed for evidence of BDD treponeme presence in the dairy farm environment, in bovine tissues and in bovine gastrointestinal (GI) tract contents. A total of 368 samples were tested using PCR assays specific for each of three currently recognised, isolated phylotypes of BDD treponemes. All environmental samples, together with insects and GI tract content samples were negative for BDD treponeme DNA from the three phylotypes. However, we identified BDD treponemes in two non-pedal bovine regions: the oral cavity (14.3% of cattle tested) and the rectum (14.8% of cattle tested). Whilst only single phylotypes were detected in the oral cavity, two of the rectal tissues yielded DNA from more than one phylotype, with one sample yielding all three BDD treponeme phylotypes. Whilst it might be considered that direct skin to skin contact may be a major transmission route of BDD treponemes, further studies are required to characterise and determine the potential contribution of oral and rectal carriage to BDD transmission.  相似文献   

The use of cortisol for the objective assessment of stress in animals: pros and cons     

Hart KA 《Veterinary journal (London, England : 1997)》2012,192(2):137-139

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基于模糊综合评价法的露营旅游产业化发展研究——以黑龙江省为例     

韩倩倩  张杰 《森林工程》2013,(3):133-137

露营旅游是当前旅游业发展过程中的一个重要课题,被列入国家＂十二五＂规划发展项目,在旅游业发展中占有举足轻重的角色和地位。针对目前黑龙江省旅游产业化发展过程中露营旅游现状,采用模糊综合评价法,在确定露营旅游的产业化发展评价指标体系及权重的基础上,对该省露营旅游的产业化发展潜力进行科学研究,得出评价结论。根据所得评价结果有针对性地给予该省发展露营旅游的相关建议,明确提出黑龙江省发展露营旅游相关措施,以期对该省露营旅游产业的发展提供帮助,同时弥补国内露营旅游的专项理论和实际研究匮乏之状。  相似文献   

ULTRASOUND APPEARANCE OF THE OUTER MEDULLA IN DOGS WITHOUT RENAL DYSFUNCTION     

Daniel Vander Hart  Matthew D. Winter  Julie Conway  Clifford R. Berry 《Veterinary radiology & ultrasound》2013,54(6):652-658

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Barriers to natural regeneration in temperate forests across the USA     

Dey  Daniel C.  Knapp  Benjamin O.  Battaglia  Mike A.  Deal  Robert L.  Hart  Justin L.  O’Hara  Kevin L.  Schweitzer  Callie J.  Schuler  Thomas M. 《New Forests》2019,50(1):11-40

New Forests - For millennia, natural disturbance regimes, including anthropogenic fire and hunting practices, have led to forest regeneration patterns that created a diversity of forest lands...  相似文献